Idoxuridinum [Inn-Latin]

• Antivirals
• Nucleic Acid Synthesis Inhibitors
• ATC:D06BB01
• ATC:J05AB02
• ATC:S01AD01

• 5IUDR
• 5idu
• Allergan 201
• Allergan 211
• Antizona
• Dendrid
• Emanil
• Heratil
• Herpe-Gel
• Herpes-Gel
• Herpesil
• Herpid
• Herpidu
• Herplex
• Herplex Liquifilm
• ID2
• IDU
• IDUR
• IUDR
• Idexur
• Idossuridina [DCIT]
• Idoxene
• Idoxuridin
• Idoxuridina [Inn-Spanish]
• Idoxuridine [Usan:Ban:Inn:Jan]
• Idoxuridinum [Inn-Latin]
• Idu Oculos
• Iducher
• Idulea
• Iduridin
• Iduviran
• Iododeoxyridine
• Iodoxuridine
• Joddeoxiuridin
• Kerecid
• Ophthalmadine
• Spectanefran
• Stoxil
• Synmiol
• Virudox

No information avaliable

C₉H₁₁IN₂O₅

No information avaliable

http://www.sciencelab.com/xMSDS-Idoxuridine-9924347

Prusoff, et al., Biochim Biophys Acta 32, 295 (1959)

354.099 g/mol

164-166^oC

<0,01 g/100 ml

Solid

-0.253

Gotas oftálmicas, ungüento oftálmico

Para su uso en la queratoconjuntivitis y queratitis causada por el virus del herpes simple.

En idoxuridina estructura química se aproxima mucho a la configuración de la timidina, uno de los cuatro componentes básicos del ADN (el material genético del virus del herpes). Como resultado, idoxuridina es capaz de para reemplazar la timidina en el paso enzimático de la replicación viral o "crecimiento". La consiguiente producción de los resultados de ADN defectuoso en un pseudostructure que no se puede infectar o destruir el tejido. En resumen, al pre- adelantarse a un bloque de construcción fundamental en el material genético del virus del herpes simple, Herplex-D solución tópica destruye la capacidad infectiva y destructivas del material viral. El virus infectó a células sólo pueden ser atacados durante el período de síntesis activa de ADN. Esto ocurre temprano en el desarrollo de la lesión del herpes simple, pero en momentos diferentes en diferentes células. Por lo tanto, idealmente, , El área afectada debe mantenerse saturada con el agente antiviral.

La absorción sistémica es poco probable que la administración ocular siguientes, incluso cuando las secreciones naso se ingieren, ya que es rápidamente vidarabina desaminados en el tracto gastrointestinal.

Hipersensibilidad o aumento de la sensibilidad de los ojos a la luz. DL50 = 3080 mg / kg (por vía oral en ratones).

Description
Idoxuridine (eye-dox-YOOR-i-deen) belongs to the family of medicines called antivirals.
Idoxuridine is used to treat virus infections of the eye.

Idoxuridine is available only with your doctor's prescription, in the following dosage forms:

Ophthalmic
Ophthalmic ointment (U.S. and Canada)
Ophthalmic solution (eye drops) (U.S. and Canada)

Proper Use of This Medicine
For patients using the eye drop form of idoxuridine:

The bottle is only partially full to provide proper drop control.
To use:
First, wash your hands. Then tilt the head back and pull the lower eyelid away from the eye to
form a pouch. Drop the medicine into the pouch and gently close the eyes. Do not blink. Keep the
eyes closed for 1 or 2 minutes to allow the medicine to come into contact with the infection.

If you think you did not get the drop of medicine into your eye properly, use another drop.
To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface
(including the eye). Also, keep the container tightly closed.

For patients using the eye ointment form of idoxuridine:

To use:
First, wash your hands. Then pull the lower eyelid away from the eye to form a pouch. Squeeze a
thin strip of ointment into the pouch. A 1-cm (approximately -inch) strip of ointment is usually
enough unless otherwise directed by your doctor. Gently close the eyes and keep them closed for 1
or 2 minutes to allow the medicine to come into contact with the infection.
To keep the medicine as germ-free as possible, do not touch the applicator tip to any surface
(including the eye). After using idoxuridine eye ointment, wipe the tip of the ointment tube with
a clean tissue and keep the tube tightly closed.

Do not use this medicine more often or for a longer time than your doctor ordered. To do so may
cause problems in the eyes. If you have any questions about this, check with your doctor.

To help clear up your infection completely, keep using this medicine for the full time of treatment,
even though your symptoms may have disappeared. Do not miss any doses.

Dosing - The dose of idoxuridine will be different for different patients. Follow your doctor's orders
or the directions on the label. The following information includes only the average doses of idoxuridine.
If your dose is different, do not change it unless your doctor tells you to do so.

The number of doses you use each day, the time allowed between doses, and the length of time you use the
medicine depend on the medical problem for which you are using idoxuridine.

For virus infections of the eye:
For eye ointment dosage form:
Adults and childrenUse every four hours during the day (five times a day).
For eye solution (eye drops) dosage form:
Adults and childrenUse every hour during the day and every two hours during the night. After the eye
condition gets better, use every two hours during the day and every four hours during the night.

Missed dose - If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost
time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage - To store this medicine:

Keep out of the reach of children.
Store in the refrigerator or in a cool place because heat will cause this medicine to break down. However,
keep the medicine from freezing. Follow the directions on the label.
Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of
the reach of children.

Virus del herpes simple